Go (mid)west young man. Three of our four picks this week come from the midwest with a Pac-12 game thrown in.
Indiana (+9.5) at No. 9 Penn State (O/U 55.5)
Pick: Penn State -9.5
No. 23 Navy (+7.5) at No. 16 Notre Dame (O/U 55)
Pick: Navy +7.5
No. 8 Minnesota (+3) at No. 20 Iowa (O/U 44.5)
Pick: Iowa -3
USC (-6.5) at Cal (O/U 48.5)
Pick: Cal +6.5